多细胞生物
噪音(视频)
拟南芥
毛状体
图灵
生物系统
拟南芥
生物
统计物理学
计算机科学
物理
遗传学
人工智能
植物
细胞
基因
突变体
图像(数学)
程序设计语言
作者
Francesca Di Patti,Yamel Ugartechea Chirino,Rinat Arbel-Goren,Tom Sharon,Aaron Castillo,Elena Alvarez–Buylla,Duccio Fanelli,Joel Stavans
标识
DOI:10.1073/pnas.2309616120
摘要
Biological patterns that emerge during the morphogenesis of multicellular organisms can display high precision at large scales, while at cellular scales, cells exhibit large fluctuations stemming from cell-cell differences in molecular copy numbers also called demographic noise. We study the conflicting interplay between high precision and demographic noise in trichome patterns on the epidermis of wild-type Arabidopsis thaliana leaves, as a two-dimensional model system. We carry out a statistical characterization of these patterns and show that their power spectra display fat tails-a signature compatible with noise-driven stochastic Turing patterns-which are absent in power spectra of patterns driven by deterministic instabilities. We then present a theoretical model that includes demographic noise stemming from birth-death processes of genetic regulators which we study analytically and by stochastic simulations. The model captures the observed experimental features of trichome patterns.
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