Copper‐Catalyzed Trifunctionalization of Heteroaryl‐Substituted 1‐Hexenes via Remote Heteroaryl Migration

A copper‐catalyzed trifunctionalization (trifluoromethylation, heteroarylation, and cyanation) of heteroaryl‐substituted 1‐hexenes via remote heteroaryl migration is reported. A variety of CF3 and heteroaryl‐containing nitriles were readily constructed under mild conditions. The reaction features high chemo‐ and regioselectivities and represents a convenient method for the synthesis of multifunctionalized molecules in organic synthesis.