Prenatal and infant exposure to antibiotics and subsequent risk of neuropsychiatric disorders in children: a nationwide birth cohort study in South Korea

医学 危险系数 队列 儿科 队列研究 人口 母乳喂养 怀孕 置信区间 内科学 环境卫生 遗传学 生物
作者
Jiyeon Oh,Ho Geol Woo,Hyeon Jin Kim,Jaeyu Park,Myeongcheol Lee,Masoud Rahmati,Sang Youl Rhee,Chanyang Min,Ai Koyanagi,Lee Smith,Guillaume Fond,Laurent Boyer,Min Seo Kim,Jae Il Shin,Seung Won Lee,Dong Keon Yon
出处
期刊:Psychiatry Research-neuroimaging [Elsevier BV]
卷期号:340: 116117-116117
标识
DOI:10.1016/j.psychres.2024.116117
摘要

We aimed to assess the association between antibiotic exposure in fetal and postnatal life (within six months after birth) and the risk of neuropsychiatric disorders in childhood. A nationwide, population-based birth cohort study(infants, n = 3,163,206; paired mothers, n = 2,322,735) was conducted in South Korea, with a mean follow-up duration of 6.8 years, using estimates of hazard ratio [HR] and 95 % confidence intervals (CIs). Following propensity score matching including the baseline variables, antibiotic exposure in both fetal (HR,1.07 [95 % CI, 1.05-1.08]) and postnatal life (1.05 [1.03-1.07]) was associated with an increased risk of overall childhood neuropsychiatric disorders. A synergistic effect was observed with prenatal and postnatal exposures (1.12 [1.09-1.15]). The risk increases with the increasing number and duration of prescriptions. Significant associations were found for both common (1.06 [1.05-1.08]) and severe outcomes (1.17 [1.09-1.26]), especially for intellectual disability (1.12 [1.07-1.17]), ADHD (1.10 [1.07-1.13]), anxiety (1.06 [1.02-1.11]), mood (1.06 [1.00-1.12]), and autism (1.03 [1.01-1.07]). When comparing siblings with different exposure statuses to consider familial factors, prenatal and postnatal exposure risk increased to 10 % (95 % CI, 6-12) and 12 % (7-17), respectively. Similar results were observed in the unmatched and health screening cohort, which considers maternal obesity, smoking, and breastfeeding. Based on these findings, clinicians may consider potential long-term risks when assessing the risk-benefit of early-life antibiotic prescription.
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