Dietary hispidulin ameliorated chemically-induced colitis by inhibiting epithelial cell ferroptosis via the ACAT2-GPX4 axis and remodeling the gut microbiota

in colitic mice. Non-targeted metabolomics results showed that hispidulin facilitated the metabolism of galactose and promoted unsaturated fatty acid biosynthesis in colitic mice. In summary, hispidulin reduced the advancement of acute colitis in mice by reducing ACAT2-mediated ferroptosis in epithelial cells, as well as altering the composition of the gut microbiota.