再生(生物学)
血小板
趋化因子
渗透(HVAC)
骨骼肌
炎症
细胞生物学
免疫学
心肌细胞
趋化性
生物
解剖
受体
生物化学
热力学
物理
作者
Flávia A. Graça,Anna Stephan,Benjamin A. Minden‐Birkenmaier,Abbas Shirinifard,Yong-Dong Wang,Fabio Demontis,Myriam Labelle
标识
DOI:10.1038/s41467-023-38624-0
摘要
Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but whether platelets promote regeneration beyond their role in hemostasis remains unexplored. Here, we find that signaling via platelet-released chemokines is an early event necessary for muscle repair in mice. Platelet depletion reduces the levels of the platelet-secreted neutrophil chemoattractants CXCL5 and CXCL7/PPBP. Consequently, early-phase neutrophil infiltration to injured muscles is impaired whereas later inflammation is exacerbated. Consistent with this model, neutrophil infiltration to injured muscles is compromised in male mice with Cxcl7-knockout platelets. Moreover, neo-angiogenesis and the re-establishment of myofiber size and muscle strength occurs optimally in control mice post-injury but not in Cxcl7ko mice and in neutrophil-depleted mice. Altogether, these findings indicate that platelet-secreted CXCL7 promotes regeneration by recruiting neutrophils to injured muscles, and that this signaling axis could be utilized therapeutically to boost muscle regeneration.
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