Palladium-catalyzed intermolecular 1,3-dienylation of propargyl esters with alcohols for constructing polysubstituted 1,3-dienes

We have developed a palladium-catalyzed propargylic substitution with alcohols as nucleophiles, wherein monohydric alcohols allow the synthesis of 2-alkoxy-1,3-dienes, while the use of diols allows the formation of 1,4-dioxane derivatives.