血小板
凝结
背景(考古学)
医学
免疫学
表型
血小板紊乱
内科学
生物
遗传学
基因
古生物学
作者
Suelyn Van Den Helm,Conor McCafferty,Natasha Letunica,Ka Ying Chau,Paul Monagle,Vera Ignjatović
标识
DOI:10.1016/j.thromres.2023.03.005
摘要
Platelets are major regulators of haemostasis and coagulation. The primary role of platelets in coagulation is to form a stable clot and stop bleeding. Studies of platelet phenotype and function in neonates and children have been restricted by the large volumes required for many common platelet function tests such as platelet aggregometry. Developmental changes in platelets have not been as well described as developmental changes in plasma coagulation proteins, and overall, platelet phenotype and function in neonates and children has been understudied when compared to adults. Recent developments in more sensitive platelet function testing methods requiring smaller blood volumes such as flow cytometry has enabled recent studies to further investigate platelet phenotype and function in neonates and children. In this review we will provide an overview of recent advances from the past five years in platelets in the context of developmental haemostasis, as well as the role of platelets in neonatal paediatric disease.
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