CLIPPER Regulates LPIN1-Mediated Mitochondrial Biogenesis and Heart Regeneration

BACKGROUND: The adult mammalian heart lacks the significant regenerative potential needed to cope with the massive loss of cardiomyocytes following myocardial infarction. Ultimately, irreversible cardiac damage leads to heart failure, which is associated with a poor prognosis. Given this, reactivating dormant regenerative processes in the injured heart represents an attractive therapeutic approach. When regeneration does occur, newly formed cardiomyocytes are derived from preexisting ones. METHODS: in cis. RESULTS: is positionally and functionally conserved in humans. CONCLUSIONS: as a promising therapeutic target for heart regeneration, acting through control of LPIN1-dependent mitochondrial biogenesis and cardiomyocyte proliferation.