软骨
再生(生物学)
纳米技术
再生医学
生物材料
生物相容性材料
生物医学工程
材料科学
化学
细胞
细胞生物学
生物
解剖
生物化学
工程类
作者
Fuxiao Wang,Zhengrong Gu,Zhengyu Yin,Wencai Zhang,Long Bai,Jiacan Su
标识
DOI:10.1186/s12951-023-02003-0
摘要
Abstract The regeneration of weight-bearing bone defects and critical-sized cartilage defects remains a significant challenge. A wide range of nano-biomaterials are available for the treatment of bone/cartilage defects. However, their poor compatibility and biodegradability pose challenges to the practical applications of these nano-based biomaterials. Natural biomaterials inspired by the cell units (e.g., nucleic acids and proteins), have gained increasing attention in recent decades due to their versatile functionality, compatibility, biodegradability, and great potential for modification, combination, and hybridization. In the field of bone/cartilage regeneration, natural nano-based biomaterials have presented an unparalleled role in providing optimal cues and microenvironments for cell growth and differentiation. In this review, we systematically summarize the versatile building blocks inspired by the cell unit used as natural nano-based biomaterials in bone/cartilage regeneration, including nucleic acids, proteins, carbohydrates, lipids, and membranes. In addition, the opportunities and challenges of natural nano-based biomaterials for the future use of bone/cartilage regeneration are discussed.
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