骨吸收
内分泌学
内科学
骨重建
肽YY
激素
平衡
葡萄糖稳态
骨质疏松症
吸收
降钙素
胰高血糖素样肽-1
胰高血糖素样肽-2
化学
生物
受体
神经肽Y受体
医学
神经肽
肽
胰岛素
生物化学
胰岛素抵抗
糖尿病
2型糖尿病
作者
Hongyu Liu,Huimin Xiao,Shih‐Yi Lin,Huan Zhou,Yong Cheng,Baocheng Xie,Daohua Xu
标识
DOI:10.3389/fphar.2024.1372399
摘要
Bone is a highly dynamic organ that changes with the daily circadian rhythm. During the day, bone resorption is suppressed due to eating, while it increases at night. This circadian rhythm of the skeleton is regulated by gut hormones. Until now, gut hormones that have been found to affect skeletal homeostasis include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), glucose-dependent insulinotropic polypeptide (GIP), and peptide YY (PYY), which exerts its effects by binding to its cognate receptors (GLP-1R, GLP-2R, GIPR, and Y1R). Several studies have shown that GLP-1, GLP-2, and GIP all inhibit bone resorption, while GIP also promotes bone formation. Notably, PYY has a strong bone resorption-promoting effect. In addition, gut microbiota (GM) plays an important role in maintaining bone homeostasis. This review outlines the roles of GLP-1, GLP-2, GIP, and PYY in bone metabolism and discusses the roles of gut hormones and the GM in regulating bone homeostasis and their potential mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI