生物传感器
生物标志物
等离子体子
材料科学
纳米技术
检出限
糖尿病肾病
化学
光电子学
色谱法
医学
肾
内科学
生物化学
作者
Shuangshuang Gao,Huili Li,Lixuan Liu,Yiming Tian,Rui Wang,Xiaoqing Pan,Wenjun Ruan,Jianyong Xiang,Anmin Nie,Kun Zhai,Bochong Wang,Congpu Mu,Tianyu Xue,Zhongyuan Liu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-04-16
标识
DOI:10.1021/acs.nanolett.4c00981
摘要
The accurate diagnosis of diabetic nephropathy relies on achieving ultrasensitive biosensing for biomarker detection. However, existing biosensors face challenges such as poor sensitivity, complexity, time-consuming procedures, and high assay costs. To address these limitations, we report a WS2-based plasmonic biosensor for the ultrasensitive detection of biomarker candidates in clinical human urine samples associated with diabetic nephropathy. Leveraging plasmonic-based electrochemical impedance microscopy (P-EIM) imaging, we observed a remarkable charge sensitivity in monolayer WS2 single crystals. Our biosensor exhibits an exceptionally low detection limit (0.201 ag/mL) and remarkable selectivity in detecting CC chemokine ligand 2 (CCL2) protein biomarkers, outperforming conventional techniques such as ELISA. This work represents a breakthrough in traditional protein sensors, providing a direction and materials foundation for developing ultrasensitive sensors tailored to clinical applications for biomarker sensing.
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