原位
荧光
化学
聚集诱导发射
斯托克斯位移
生物物理学
外体
生物相容性
光化学
纳米技术
材料科学
微泡
生物化学
小RNA
物理
生物
有机化学
基因
量子力学
作者
Jipeng Ding,Runsha Xiao,Anyao Bi,Guanyang Chen,Nengwei Zhang,Zihua Chen,Xueping Feng,Wenbin Zeng
标识
DOI:10.1016/j.cclet.2023.108273
摘要
Exosomes play significant roles in physiological and tumorigenic processes and it is desirable to visualize and track the exosomes. Herein, a novel amphiphilic fluorescent probe HBT-Exo based on excited-state intramolecular proton transfer (ESIPT) mechanism is reported for exosome-labeling. Its ESIPT characteristics were confirmed by both theory calculation and experimental observation, which enable the probe to show a large Stokes shift as well as near-infrared (NIR) keto-form emission. HBT-Exo displayed excellent biocompatibility and remarkable efficiency for exosome-labeling in gastric cancer cells. Furthermore, the labeled exosomes were successfully applied for the real-time in situ imaging in mouse models.
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