吉西他滨
癌症研究
PI3K/AKT/mTOR通路
蛋白激酶B
医学
细胞凋亡
雷布
药理学
化学
内科学
癌症
转录因子
NFKB1型
生物化学
基因
作者
Dan Wang,Kun Yan,Hongxing Yu,Haocheng Li,Wei Zhou,Yaqiang Hong,Shuning Guo,Yi Wang,Cheng Xu,Changcun Pan,Yujie Tang,Nian Liu,Wei Wu,Liwei Zhang,Qiaoran Xi
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-12-14
卷期号:84 (4): 598-615
被引量:14
标识
DOI:10.1158/0008-5472.can-23-0394
摘要
Gemcitabine activates p53 and induces apoptosis to elicit antitumor effects in H3.3K27M DIPG, which can be enhanced by blocking NF-κB and PI3K/AKT signaling with fimepinostat, providing a synergistic combination therapy for DIPG.
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