纳米颗粒
纳米技术
细胞凋亡
材料科学
过氧化氢
活性氧
体内
程序性细胞死亡
线粒体
细胞内
生物物理学
化学
癌症研究
生物
生物化学
生物技术
作者
Guanzhong He,Yongchun Pan,Fei Zeng,Shurong Qin,Xiaowei Luan,Qi Lu,Changsheng Xie,Pengfei Hu,Yanfeng Gao,Jingjing Yang,Bangshun He,Yujun Song
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-03-12
被引量:1
标识
DOI:10.1021/acsnano.3c12796
摘要
Cuproptosis has drawn enormous attention in antitumor material fields; however, the responsive activation of cuproptosis against tumors using nanomaterials with high atom utilization is still challenging. Herein, a copper-based nanoplatform consisting of acid-degradable copper hydride (CuH) nanoparticles was developed via a microfluidic synthesis. After coating with tumor-targeting hyaluronic acid (HA), the nanoplatform denoted as HA-CuH-PVP (HCP) shows conspicuous damage toward tumor cells by generating Cu+ and hydrogen (H2) simultaneously. Cu+ can induce apoptosis by relying on Fenton-like reactions and lead to cuproptosis by causing mitochondrial protein aggregation. Besides, the existence of H2 can enhance both cell death types by causing mitochondrial dysfunction and intracellular redox homeostatic disorders. In vivo experimental results further exhibit the desirable potential of HCP for killing tumor cells and inhibiting lung metastases, which will broaden the horizons of designing copper-based materials triggering apoptosis and cuproptosis for better antitumor efficacy.
科研通智能强力驱动
Strongly Powered by AbleSci AI