优势比
荟萃分析
SLCO1B1型
科克伦图书馆
医学
SNP公司
科学网
内科学
药理学
单核苷酸多态性
基因型
生物
基因
遗传学
作者
Ming Zhu,Xinyu Chen,Zhuolu Hao,Yunjiao He,Bing Han,Shaowen Tang
出处
期刊:Pharmacogenomics
[Future Medicine]
日期:2023-12-01
卷期号:24 (18): 931-942
标识
DOI:10.2217/pgs-2023-0168
摘要
Aims: To evaluate the association between SLCO1B1 gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxicity (ATDH). Methods: We searched the PubMed, Cochrane Library, Embase, Web of Science, Wan Fang and China National Knowledge Infrastructure database from inception to 2022. Results: Nine case-control studies with 1129 cases and 2203 controls were included. Among four SNPs reported in two or more studies, the final results indicated that SNP rs4149014 was significantly associated with decreased ATDH risk (dominant model, odds ratio: 0.73; 95% CI: 0.55-0.97; p = 0.03; allele model, odds ratio: 0.69; 95% CI: 0.55-0.86; p = 0.001), and the trial sequential analysis also confirmed this significant association. Conclusion:SLCO1B1 gene SNP rs4149014 was significantly associated with lower risk of ATDH susceptibility.
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