神经保护
神经科学
干预(咨询)
熊果苷
记忆障碍
大鼠模型
心理学
星形胶质增生
医学
生物
中枢神经系统
精神科
认知
内科学
生物化学
作者
Sahand Ashrafpour,Mohammad-Javad Nasr-Taherabadi,Alie Sabouri-Rad,Soheila Hosseinzadeh,Fereshteh Pourabdolhossein
标识
DOI:10.1016/j.bbr.2024.115041
摘要
Cognitive impairment (CI) and memory deficit are prevalent manifestations of multiple sclerosis (MS). This study explores the therapeutic potential of arbutin on memory deficits using a rat hippocampal demyelination model induced by lysophosphatidylcholine (LPC). Demyelination was induced by bilateral injection of 1% LPC into the CA1 area of the hippocampus, and the treated group received daily arbutin injections (50mg/kg, i.p) for two weeks. Arbutin significantly improved memory impairment 14 days post-demyelination as assessed by Morris water maze test. Histological and immunohistochemical analyses demonstrated that arbutin reduced demyelination suppressed pro-inflammatory markers (IL-1β, TNF-α) and increased anti-inflammatory cytokine IL-10. Arbutin also diminished astrocyte activation, decreased iNOS, enhanced anti-oxidative factors (Nrf2, HO-1), and exhibited neuroprotective effects by elevating myelin markers (MBP) and brain derived neurotrophic factor (BDNF). These findings propose arbutin as a potential therapeutic candidate for multiple sclerosis-associated memory deficits, warranting further clinical exploration.
科研通智能强力驱动
Strongly Powered by AbleSci AI