An Adipose-Derived Stem Cell Exosome Sheet Promotes Oral Mucosal Wound Healing

OBJECTIVE: Oral mucosal wound healing is not completely understood, and effective therapies are lacking. This study explores the potential of an adipose-derived stem cell (ADSC) exosome sheet in enhancing intraoral wound healing in rats. APPROACH: = 4 per group) were applied to rat oral mucosal fibroblasts to assess migration speed. RESULTS: < 0.0001). INNOVATION: This is the first study to demonstrate the pro-wound healing effects of an ADSC exosome sheet on intraoral wounds. This paves the way for future research and clinical applications of ADSC exosomes in mucosal wound healing. CONCLUSIONS: Application of an ADSC-exo to rat mucosal wounds significantly improved wound healing. Mechanistically, these effects may be linked to upregulated activity of the TGF-β/Smad pathway.