Efficient Transition Metal‐Free Potassium Persulfate Promoted Regioselective Ketonization of Vinyl Azides: Advancing α‐Thiocyanated Ketones Synthesis

Abstract The development of a highly effective regioselective ketonization of vinyl azides advancing α‐thiocyanated ketones without transition metals using potassium persulfate as a promoter represents a significant milestone in organic synthesis. This innovative technique enables the direct incorporation of a thiocyanate group (─SCN) into specific positions of vinyl azide compounds advances the synthesis of α‐thiocyanated ketones, all without the necessity of other catalyst. The reaction utilizes a combination of potassium persulfate with potassium thiocyanate, allowing for straightforward execution at room temperature under normal atmospheric conditions. The presented protocol not only advances the field of α‐thiocyanated ketone synthesis but also contributes to greener and more sustainable synthetic strategies.