Nano and Microplastics: Unveiling Their Profound Impact on Endocrine Health

Plastics are extensively used materials with a long environmental lifespan, posing significant risks to human health and the environment. Global plastic consumption has surged, with plastic waste expected to triple by 2060. The primary concern is the breakdown of plastics into nano and micro-sized particles, which can enter the body and have been detected in various organs and tissues.This review systematically examines the effects of micro and nanoplastics (MNPs) on the endocrine system using in vitro and in vivo experimental models. Following PRISMA guidelines, articles were sourced from databases like PubMed, Web of Science, and Scopus. After screening for relevance and removing duplicates and non-English articles, 103 articles focusing on the endocrine effects of MNPs were selected.MNPs can disrupt endocrine functions, altering reproductive hormones and gene expression patterns. In vivo exposure to MNPs increases inflammatory markers such as TNF-α, IL-6, IL-1β, and NF-κB, leading to apoptosis, inflammation, and oxidative stress. These disruptions impact the gonads, thyroid glands, and hormone secretion from the pituitary and hypothalamus. Most studies focus on terrestrial animals, with polystyrene being the most commonly used polymer.Future research should explore various plastic polymers, longer exposure durations, a broader range of concentrations, and human-level studies to better understand the toxicity of plastic particles. Reducing exposure to these pollutants requires legal changes, consumer behavior adjustments, and increased public awareness. Understanding the underlying processes can help propose methods to mitigate risks and protect human health.