Cover Picture: Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 (Angew. Chem. Int. Ed. 47/2022)

A lone 4-oxo-β-lactam molecule moves towards the catalytic site of an illuminated dipeptidyl peptidase 8 (DPP8) in a vast universe of chemical space. Achieving DPP8/9 selectivity has remained a challenge in chemical biology. The 4-oxo-β-lactams, identified by a chemoproteomics platform as DPP8/9 inhibitors may hold the key to the highly sought DPP8/9 selectivity via an unprecedented DPP8-specific mechanism, as demonstrated through X-ray diffraction by Markus Kaiser, Rui Moreira et al. in their Research Article (DOI: 10.1002/anie.202210498).