Design, synthesis, and antifungal activity of novel pogostone‐based derivatives containing amide active moieties

BACKGROUND: Phytopathogenic fungi cause substantial yield losses in various crops. Although traditional chemical fungicides remain effective, adverse effects have become increasingly apparent. The development of fungicides guided by natural products can alleviate these negative impacts to a certain extent. RESULTS: elevated intracellular reactive oxygen species levels, disrupted mitochondrial function and cellular integrity, and ultimately inhibited mycelial growth, leading to apoptosis. CONCLUSION: was identified. This not only facilitates the screening of candidate compounds for eco-friendly and highly effective fungicides, but also provides guidance and novel strategies for the derivatization and synthesis of pogostone. © 2025 Society of Chemical Industry.