上睑下垂
声动力疗法
光动力疗法
癌症研究
乳腺癌
免疫系统
医学
光敏剂
阿霉素
单线态氧
生物相容性
癌症
生物安全
材料科学
化学
免疫学
病理
内科学
化疗
炎症体
炎症
氧气
冶金
有机化学
作者
Sijie Wen,Dongsheng Tang,Lingpu Zhang,Hanchen Zhang,Zheng Cao,Kong Wai Tan,Xiaojun Wang,Haihua Xiao,Kun Shang
标识
DOI:10.1002/advs.202508155
摘要
Abstract Zinc(II) complexes have emerged as promising antitumor agents due to their favorable biosafety and biocompatibility, and demonstrated effectiveness in photodynamic therapy (PDT). However, their therapeutic potential is limited by the poor tissue penetration of PDT agents. Herein, a novel zinc(II) complex designed for sonodynamic therapy (SDT), capable of producing substantial amounts of singlet oxygen upon ultrasonic activation, is introduced. This sonosensitizer effectively induces pyroptosis in breast cancer cells, significantly promoting the antitumor immune response. This work represents the first exploration of zinc(II) complexes in SDT, establishing a new avenue for enhanced therapeutic outcomes against breast cancer.
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