ABSTRACT This study summarizes the nursing management of a patient with cerebral infarction and sacrococcygeal Stage 2 pressure ulcer, focusing on the effectiveness of local oxygen therapy combined with human albumin. Patients are evaluated for the risk of pressure ulcers and nutritional deficiencies upon admission. We applied topical oxygen therapy combined with human albumin for dressing changes, during which the healing of pressure ulcers is assessed promptly. The pressure ulcer completely healed within 1 week, The new method of pressure ulcer care, which combines local oxygen therapy with human blood albumin, has been shown to shorten wound healing time, enhance nursing effectiveness, and provide a more efficient and feasible nursing technology for the clinical promotion of pressure ulcer management.