光动力疗法
医学
养生
葡萄酒色斑
红斑
血卟啉
体内
内科学
外科
化学
生物
光学
物理
生物技术
有机化学
激光器
作者
Sheng Zhang,Xiuwei Wang,Hongguang Chen,Huina Cao,Hongli Zhang,Ming Yang,Yan Zhu,Qin Qin,Xiaoyan Liu,Jianhua Wang,Gaolei Zhang
摘要
Abstract Hematoporphyrin monomethyl ether‐photodynamic therapy (HMME‐PDT) has achieved encouraging clinical outcomes in adult port‐wine stain (PWS). Optimal treatment option for children with PWS was minimal. To compare whether the clinical effectiveness of HMME‐PDT with the 5‐min (fast) administration treatment regimen (FATR) was better than the 20‐min (slow) administration treatment regimen (SATR) for PWS of children in vivo and in vitro. Thirty‐four children with PWS were divided into two groups including FATR and SATR. The two groups received three times HMME‐PDT, respectively. Treatment efficacy and safety were evaluated in vivo and in vitro . Erythema index (EI) was used to evaluate the clinical outcomes. Both FATR and SATR were effective and safe in children with PWS after HMME‐PDT. There were significance differences between the two groups in reductions of EI after the second treatment ( p < 0.001) and the third treatment ( p < 0.001) with HMME‐PDT. The serum HMME concentration reach the peak level at short time compare with SATR group. A significance increased superoxide levels were observed in FATR group compare to SATR groups in vitro ( p < 0.05). Our study suggested that HMME‐PDT was effective and safe for children with PWS, the therapy regimen with FATR was better in clinical efficacy than that of the SATR.
科研通智能强力驱动
Strongly Powered by AbleSci AI