Adenosine A 2A Receptor in the Choroid Plexus Modulates Ischemia–Reperfusion Injury in the Cortex

BACKGROUND: R) is recognized as an important regulator of ischemic brain injury, but their action sites remain undefined. METHODS AND RESULTS: R antagonist KW6002 during the reperfusion period attenuated the injury with reduced neutrophil infiltration in the ChP. CONCLUSIONS: R in ChP as a pivotal regulator of I/R injury in the cortex, modulating ChP gateway activity and CSF production, providing a promising therapeutic target for stroke management.