Bisphenol A exposure links to exacerbation of memory and cognitive impairment: A systematic review of the literature

This systematic-review probes the deleterious outcome of Bisphenol A (BPA) exposure on cognition/memory by scrutinizing the extant preclinical studies on this focus, to promote apprehension about this environmental toxin among the general population with a long-term goal to build a plastic (BPA)-free future. Bibliographic databases, including Scopus, ProQuest, PubMed, Google Scholar, DOAJ, and ScienceDirect were searched for preclinical reports assessing the impact of BPA exposure on memory/cognition. The review protocol has been published in PROSPERO with the registration number CRD42022333965. The SYRCLE's RoB tool was implemented to assess the risk of bias in the retrieved reports. The review finally comprehended 22 reports. Results of 22 reports compositely suggest that maternal exposure to BPA raises the likelihood of the fetus enduring neuro-developmental dysfunction, which may manifest as memory/cognitive decline. BPA impairs memory and cognition by binding to estrogen receptors, inhibiting ERK–CREB–BDNF signaling pathway, altering the expression of synaptic proteins, impairing the morphology of pyramidal neurons in the hippocampus, dysregulation of thyroid hormones, and altering the neurotransmitter levels. • Bisphenol-A is an Endocrine-disrupting compound, used in the production of plastics. • Canned food and beverages are regarded as a major source of Bisphenol A exposure. • Bisphenol-A imparts memory and cognitive impairment through estrogen antagonism. • Bisphenol-A induce synaptic toxicity and alter the neurotransmitter levels. • Bisphenol-A cause thyroid impairment which contributes to memory/cognitive decline.