Stereospecific/stereoselective nickel catalyzed reductive cross-coupling: An efficient tool for the synthesis of biological active targeted molecules

Reductive cross-electrophile transformations have recently been made into a robust and long-lasting synthetic technique for the production of specific CC bonds. The use of inexpensive and plentiful electrophiles eliminates the need for pre-formation and handling of organometallics. In stereospecific reductive cross-coupling, nickel is one of the most cost-effective and flexible transition metals. This paper examines current developments in nickel catalyzed reductive cross-coupling reactions and their potential application for the synthesis of biologically active molecules over the previous nine years.