生物医学中的光声成像
内窥镜检查
超声波
超声波传感器
放射科
对比度(视觉)
生物医学工程
医学
计算机科学
计算机视觉
光学
物理
作者
Joon-Mo Yang,Christopher P. Favazza,Ruimin Chen,Junjie Yao,Xiaoxiao Cai,Konstantin Maslov,Qifa Zhou,K. Kirk Shung,Lihong V. Wang
出处
期刊:Nature Medicine
[Springer Nature]
日期:2012-07-15
卷期号:18 (8): 1297-1302
被引量:356
摘要
At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave-based image contrast fundamentally limits its ability to provide physiologically specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically relevant depths, ideal for imaging soft tissues. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, thereby enabling multimodality imaging with complementary contrast. Here we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and show its ability to image internal organs in vivo, thus illustrating its potential clinical application.
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