癌症
癌细胞
细胞器
纳米技术
肿瘤进展
计算生物学
细胞生物学
生物
化学
材料科学
遗传学
作者
Danfeng Cai,Zhe Liu,Jennifer Lippincott‐Schwartz
标识
DOI:10.1016/j.tibs.2021.01.002
摘要
Liquid–liquid phase separation (LLPS) has emerged in recent years as an important physicochemical process for organizing diverse processes within cells via the formation of membraneless organelles termed biomolecular condensates. Emerging evidence now suggests that the formation and regulation of biomolecular condensates are also intricately linked to cancer formation and progression. We review the most recent literature linking the existence and/or dissolution of biomolecular condensates to different hallmarks of cancer formation and progression. We then discuss the opportunities that this condensate perspective provides for cancer research and the development of novel therapeutic approaches, including the perturbation of condensates by small-molecule inhibitors.
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