奥西默替尼
T790米
医学
肺癌
转移
吉非替尼
肺
癌症
腺癌
病理
肿瘤科
放射科
内科学
表皮生长因子受体
ROS1型
作者
Takao Sakaizawa,Masayuki Toishi,Keisuke Ozawa,Hideki Nishimura,Takashi Maruno,Yusuke Suzuki
出处
期刊:PubMed
日期:2019-08-01
卷期号:46 (8): 1291-1293
摘要
A 63-year-old woman underwent right lower lobectomy and mediastinal dissection for lung cancer. At 5 years and 5 months after surgery, chest computed tomography revealed multiple liver metastasis. EGFR gene mutations of L858R and T790M were detected in both the primary lung cancer lesion and the liver metastasis specimen. Gefitinib was initiated as the first-line treatment, but the tumors increased in size. Osimertinib, as second-line treatment, was remarkably effective against the liver metastatic lesions and it maintained a partial response for approximately 1 year. Thus, osimertinib was effective for liver metastasis of lung cancer with EGFR mutations of L858R and T790M.
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