To Treat or Not? Remission Induction of Acquired von Willebrand Syndrome Secondary to Chronic Lymphocytic Leukemia: A Case Report

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder caused by a reduction in the levels and/or activity of von Willebrand factor (VWF) and presents similarly to its inherited alter ego, von Willebrand disease, from a laboratory perspective. AVWS is a rare entity with a reported estimated prevalence of 0.04%, although it may be underreported and often missed.1 The diagnosis of AVWS is based on the new onset of bleeding in an individual who lacks a personal or family bleeding history, laboratory testing compatible with abnormalities in VWF, and the presence of a condition known to cause AVWS.