医学
胃肠病学
内科学
胃蛋白酶
发育不良
人口
胃粘膜
癌症
活检
胃
生物化学
环境卫生
酶
化学
作者
Olga Sjomina,Jelizaveta Pavlova,Ilva Daugule,Pavel Janovic,Ilze Ķikuste,Aigars Vanags,Ivars Tolmanis,Dace Rudzīte,Inese Poļaka,Ilona Kojalo,Inta Liepniece-Karele,Sergejs Isajevs,Daiga Šantare,Valdis Pīrāgs,Jelena Pahomova,Vilnis Dzērve,Lilian Tzivian,Andrejs Ērglis,Mārcis Leja
出处
期刊:Journal of Gastrointestinal and Liver Diseases
[Romanian Society of Gastroenterology and Hepatology]
日期:2018-03-31
卷期号:27 (1): 11-17
被引量:11
标识
DOI:10.15403/jgld.2014.1121.271.pep
摘要
Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I< 70 ng/ml and PG I/PG II ratio < 3), with strongly decreased (PG I< 30 ng/ml and PG I/PG II ratio < 2), and with normal PG level. Biopsy with H. pylori detection was performed (updated Sydney system).Results: Results from 259 patients were analyzed. Pepsinogens were decreased in 133 (51.4%), H. pylori was positive in 177 (66.0%) cases. Mean age was significantly lower in patients with normal compared to strongly decreased PG level group (52.8 vs. 64.1 years, p<0.001). Prevalence of severe corpus atrophy was higher in the strongly decreased compared to the normal PG test group: 7.0% vs. 0%; the same tendency was noted in the distribution of OLGA stages III-IV – 10.5% and 0.0%, OLGIM stages III-IV – 3.5% and 0%, and low-grade dysplasia – 15.8% and 2.4% (p<0.05). Two cases of gastric cancer were found; both presented decreased PG levels. A strong association between H. pylori eradication and PG ratio dynamics was found (p<0.05).Conclusions: All high-risk lesions were found in the decreased PG test groups; two cancer cases were revealed.However, PG demonstrated low specificity and low value of repeated testing. The value of PG as a sole test for gastric cancer risk is limited.
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