Discovery of Imidazo[2,1- b ][1,3,4]thiadiazole-Based MNK Inhibitors with Anti-inflammatory Efficacy via Dual Suppression of eIF4E Phosphorylation and NF-κB Signaling

suppressed eIF4E phosphorylation, NF-κB signaling, and macrophage polarization, thereby reducing pro-inflammatory cytokines and oxidative stress. These results suggest that MNK inhibition is a promising strategy for treating inflammatory diseases by targeting both inflammation and oxidative stress.