Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD

Our study elucidates core regulatory role of ROS/ITGA3-FAK-YAP axis in AT2 cells renewal dysfunction in COPD by integrating single-cell genomics, preclinical models, and functional organoid studies, demonstrating ROS/ITGA3 as a new promising avenue for therapeutic intervention of COPD regeneration therapy.