计算生物学
癌症
药物发现
医学
药物开发
生物信息学
生物
癌症治疗
精密医学
癌症研究
药品
药物重新定位
药理学
抗药性
作者
Joachim Rudolph,Jeff Settleman,Shiva Malek
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2021-04-01
卷期号:11 (4): 815-821
被引量:5
标识
DOI:10.1158/2159-8290.cd-21-0260
摘要
Technology advancement and the courage to challenge dogma have been key elements that have continuously shifted druggability limits. We illustrate this notion with several recent cancer drug-discovery examples, while also giving an outlook on the opportunities offered by newer modalities such as chemically induced proximity and direct targeting of RNA. Treatment resistance is a major impediment to the goal of durable efficacy and cure, but the confluence of new biological insights, novel drug modalities, and drug combinations is predicted to enable transformative progress in this decade and beyond.
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