医学
慢性阻塞性肺病
嗜酸性粒细胞增多症
痰
哮喘
内科学
肺病
免疫学
气道
回顾性队列研究
嗜酸性粒细胞
肺嗜酸性粒细胞增多
作者
Maria Laura Bartoli,Manuela Latorre,Barbara Vagaggini,Dario Nieri,Silvana Cianchetti,Antonella Di Franco,Alessandro Celi,Pierluigi Paggiaro
标识
DOI:10.1016/j.rmed.2021.106672
摘要
Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use, suggesting that airway eosinophilia may be associated to a lower COPD severity and some functional "asthma-like" characteristics, therefore explaining the better response to ICS in this subgroup of patients.
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