神经酰胺
经皮失水
角质层
安慰剂
势垒函数
敏感皮肤
乳酸
鞘脂
化学
医学
内分泌学
鞘磷脂
食品科学
脂质信号
内科学
鞘氨醇
药理学
皮肤病科
生物化学
生物
病理
细胞生物学
细胞凋亡
替代医学
细菌
遗传学
作者
Hiroshi Nojiri,Koichi Ishida,Xueqiu Yao,Wei Liu,Genji Imokawa
标识
DOI:10.1007/s00403-018-1833-9
摘要
We determined whether compensating ceramides in the stratum corneum (SC) may ameliorate the impaired barrier function and subsequently attenuate the enhanced skin sensitivity. Treatment for 4 weeks with the ceramide complex cream or the placebo cream significantly ameliorated the intensity of lactic acid sensations in 39 female subjects with sensitive skin, the degree of which was attenuated to a greater extent at 1 week by the ceramide complex cream compared with the placebo cream. The amelioration of skin sensations was accompanied by a significant increase in total ceramide content in the SC elicited by the ceramide complex cream that was significantly more effective than the placebo cream at 4 weeks. Consistently, TEWL and conductance values were significantly decreased or increased at 1 and 4 weeks, respectively, to a greater extent by the ceramide complex cream than by the placebo cream. TEWL levels were significantly correlated with the increased levels of SC total ceramide in the ceramide complex cream-treated skin but not in the placebo cream-treated skin. Thus, the amelioration of lactic acid sensations by topical application of a ceramide complex cream, provides a deep insight into the pathophysiology of sensitive skin as a reduced barrier function-dependent sub-clinical sensory response.
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