材料科学
聚二甲基硅氧烷
显微镜
玻璃微球
光学显微镜
显微镜
制作
光学
表征(材料科学)
微球
分辨率(逻辑)
扫描电子显微镜
纳米技术
光电子学
复合材料
病理
工程类
人工智能
物理
医学
替代医学
化学工程
计算机科学
摘要
Microsphere-assisted imaging can be incorporated onto conventional light microscopes allowing wide-field and flourescence imaging with enhanced resolution. We demonstrated that imaging of specimens containing subdiffraction-limited features is achievable through high-index microspheres embedded in a transparent thin film placed over the specimen. We fabricated novel microsphere-embedded microscope slides composed of barium titanate glass microspheres (with diameter ~10-100 μm and refractive index~1.9-2.2) embedded in a transparent polydimethylsiloxane (PDMS) elastomer layer with controllable thickness. We characterized the imaging performance of such microsphere-embedded devices in white-light microscopies, by measuring the imaging resolution, field-of-view, and magnification as a function of microsphere size. Our results inform on the design of novel optical devices, such as microsphere-embedded microscope slides for imaging applications.
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