抗辐射性
自噬
辐射敏感性
癌症研究
放射治疗
癌症
DNA损伤
生物
程序性细胞死亡
细胞凋亡
DNA修复
辐射耐受性
缺氧(环境)
癌细胞
癌症干细胞
细胞生物学
医学
DNA
化学
遗传学
内科学
有机化学
氧气
作者
Yan Yang,Yan Yu,Xi Yang,Hongcheng Zhu,Qing Guo,Xiaochen Chen,Hao Zhang,Hongyan Cheng,Xinchen Sun
出处
期刊:Tumor Biology
[SAGE]
日期:2015-05-07
卷期号:36 (6): 4079-4087
被引量:39
标识
DOI:10.1007/s13277-015-3496-x
摘要
Autophagy differs from apoptosis and is independent of phagocytes by the appearance of autophagosomes, autolysosomes, and complete nuclei in the cell. This process significantly contributes to the antineoplastic effects of radiation. Radiation is an important strategy in cancer treatment; however, many types of cancer show radioresistance. The effects of radiotherapy are affected by factors, including the degree of tumor tissue hypoxia, the ability to repair DNA damage, and the presence of cancer stem cells. We review the relationships among autophagy, the three factors in cancer radiation, and the possible underlying molecular mechanisms. The therapeutic implications of these relationships and mechanisms in clinical settings are also discussed.
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