Stereoselective Synthesis of Monofluoroalkenes Using Cross-Coupling Reactions

Various methods for the stereoselective synthesis of fluorohaloalkenes and fluoroalkenyl metals are developed. The resulting fluorohaloalkenes and fluoroalkenyl metals are used for the cross-coupling reaction to synthesize monofluoroalkenes stereoselectively. The cross-coupling reactions using fluorohaloalkenes and fluoroalkenyl metals are a powerful tool for the stereoselective synthesis of polyfunctionalized fluoroalkenes and alkadienes.