Coumarins permeability in Caco-2 cell model

ObjectivesThe presence of coumarins in human diet, their multiple pharma***ćological properties and occurrence in various herbal remedies represent significant reasons to explore their membrane permeability, as a first event contributing to coumarins oral bioavailability. Thus, we evaluated the permeability and cytotoxicity of 18 coumarins, with different substitution patterns involving OH, OCH3 and CH3 groups.