秀丽隐杆线虫
MAPK/ERK通路
细胞命运测定
串扰
细胞生物学
Notch信号通路
信号转导
生物
激酶
表皮生长因子受体
转录因子
受体
遗传学
基因
光学
物理
作者
Andrew S. Yoo,Carlos Bais,Iva Greenwald
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2004-01-30
卷期号:303 (5658): 663-666
被引量:235
标识
DOI:10.1126/science.1091639
摘要
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degrees fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2 degrees fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2 degrees cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.
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