长春花
微管蛋白
长春碱
紫杉醇
秋水仙碱
微管
长春花生物碱
抗有丝分裂剂
有丝分裂
生物
生物碱
主轴装置
长春新碱
药理学
结合位点
化学
生物化学
细胞生物学
细胞分裂
立体化学
细胞
癌症
遗传学
化疗
环磷酰胺
作者
Allan M. Jordan,John A. Hadfield,Nicholas J. Lawrence,Alan T. McGown
标识
DOI:10.1002/(sici)1098-1128(199807)18:4<259::aid-med3>3.0.co;2-u
摘要
Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997. © 1998 John Wiley & Sons, Inc., Med Res Rev, 18, No. 4, 259–296, 1998.
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