Nanofiltered C1 Inhibitor Concentrate for Treatment of Hereditary Angioedema

BL Zuraw, PJ Busse, M White. N Engl J Med. 2010;363(6):513–522 To determine the efficacy of nanofiltered C1 inhibitor concentrate in the management of hereditary angioedema (HAE). Subjects were from 2 studies; the lowest age was 6 years (median age: 36 years). Both studies compared an intravenous dose of 1000 U of nanofiltered C1 inhibitor concentrate in the management of HAE. The first study end point was the time to unequivocal relief of symptoms during an acute attack of HAE. The second study was …