Electrochemiluminescent Detection of Chlorpromazine by Selective Preconcentration at a Lauric Acid-Modified Carbon Paste Electrode Using Tris(2,2‘-bipyridine)ruthenium(II)

A new detection scheme for the determination of adsorbable coreactants of Ru(bpy)32+ electrochemiluminescent reaction is presented. It is based on selective preconcentration of coreactant onto an electrode, followed by Ru(bpy)32+ electrochemiluminescent detection. The coreactant employed is chlorpromazine. It was sensitively detected after 5-min preconcentration onto a lauric acid-modified carbon paste electrode. The linear concentration range was found to occur from 1 × 10-8 to 3 × 10-6 mol L-1 with a detection limit of 3.1 × 10-9 mol L-1. The total analysis time is less than 10 min. As a result of selective preconcentration and medium exchange, such remarkable selectivity is achieved that reproducible quantitation of chlorpromazine in urine is possible.