Asymmetric Hydrophosphonylation of α‐Ketoesters Catalyzed by Cinchona‐Derived Thiourea Organocatalysts

Naturally catalytic: The cinchonidine- and cinchonine-derived bifunctional thiourea organocatalysts 1 a and 1 g (see picture) have been applied in the asymmetric hydrophosphonylation of aromatic and heteroaromatic α-ketoesters for the first time, obtaining S and R products in high yields with good to excellent enantioselectivities (up to 91 % ee). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.