自身免疫
免疫学
免疫系统
自身免疫性疾病
多发性硬化
疾病
获得性免疫系统
1型糖尿病
皮肌炎
类风湿性关节炎
银屑病
多发性肌炎
医学
长非编码RNA
生物
核糖核酸
糖尿病
遗传学
基因
抗体
内科学
内分泌学
作者
Guo-Cui Wu,Hai‐Feng Pan,Rui‐Xue Leng,Deguang Wang,Xiang-Pei Li,Xiaomei Li,Dong‐Qing Ye
标识
DOI:10.1016/j.autrev.2015.05.004
摘要
Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).
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