Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression

Abstract Surgery alone is curative for most children with localized MYCN ‐non‐amplified neuroblastoma. However, 10–15% will develop recurrent loco‐regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN ‐non‐amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole‐genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole‐genome analysis in children with localized neuroblastoma is warranted. Pediatr Blood Cancer 2013;60:332–335. © 2012 Wiley Periodicals, Inc.