PTEN公司
考登综合征
甲状腺癌
乳腺癌
医学
癌症
肿瘤科
子宫内膜癌
内科学
累积发病率
种系突变
癌症综合征
生物
遗传学
突变
队列
PI3K/AKT/mTOR通路
基因
细胞凋亡
作者
Virginie Bubien,Françoise Bonnet,Véronique Brouste,Stéphanie Hoppe,Emmanuelle Barouk-Simonet,Albert David,Patrick Edery,Armand Bottani,Valérie Layet,Olivier Caron,Brigitte Gilbert‐Dussardier,Capucine Delnatte,Catherine Dugast,Jean‐Pierre Fricker,Dominique Bonneau,Nicolas Sévenet,Michel Longy,F. Caux,French Cowden Disease Network
标识
DOI：10.1136/jmedgenet-2012-101339
摘要
This study shows a considerably high cumulative risk of cancer for patients with PHTS, mainly in women without clear genotype-phenotype correlation for this cancer risk. New recommendations for the management of PHTS patients are proposed.
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