医学
帕妥珠单抗
曲妥珠单抗
拉帕蒂尼
心脏毒性
荟萃分析
射血分数
肿瘤科
内科学
乳腺癌
优势比
科克伦图书馆
心力衰竭
癌症
心脏病学
化疗
作者
Hossein A. Rahmani,Alireza Shahriary,Mohammad Ali Sheikhi,Ahmad Ebadi,Hannaneh Davoodzadeh
出处
期刊:Panminerva Medica
[Edizioni Minerva Medica]
日期:2017-01-01
卷期号:59 (1)
被引量:7
标识
DOI:10.23736/s0031-0808.16.03201-8
摘要
Breast cancer is the most common type of cancer in women. Many antineoplastic agents used to treat breast cancer have potentially cardiotoxic effects and may lead to chemotherapy induced cardiomyopathy and heart failure. We conducted a meta-analysis to clarify the applications of cardiotoxicity in breast cancer.A published literature search was performed through PubMed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using χ2 and I2 statistics. We performed a formal meta-analysis using summary measures from these studies.In total, 9 published studies were included in the final analysis. The combined analysis revealed that there was non-significant regardless of the statistical ejection fraction (OR=0.98, 95% CI: 0.63-1.54, P=0.96) and left ventricular ejection fraction (OR=1.04; 95% CI: 0.69-1.56, P=0.85) decline method used. Additionally, the pooled OR was 0.99 (95% CI: 0.79-1.28) for the trastuzumab plus lapatinib combination, and 1.00 (95% CI: 0.88-1.13) for the trastuzumab plus pertuzumab combination.In this meta-analysis, there was evidence indicated that there was not a significant decrease on LVEF and EF in patients who received trastuzumab plus lapatinib and trastuzumab plus pertuzumab combination. Our study suggests that the combination of two anti-HER2 agents does not significantly increase the risk for adverse compared with anti-HER2 monotherapy in patients with adequate cardiac function prior to start of therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI